Systemic sclerosis fibroblasts, pIL-1 translocation was shown to depend on binding | D1T
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Systemic sclerosis fibroblasts, pIL-1 translocation was shown to depend on binding to HS1associated protein X-1 (HAX-1) and induce the expression of IL-6 and pro-collagen (Figure 2).129 Interestingly, HAX-1 was also found to interact with the cleaved IL-1 N-terminal domain.130 Together, these studies suggest that the nuclear function of pIL-1 is predominantly dependent on its N-terminal domain. Up
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